View a list of resources dedicated to supporting your journey with cancer.
Find Support
Support and knowledge is one of the most powerful tools one can have in the fight
against cancer. Support can be from a loved one making dinner to a cancer survivor
sharing their story and knowledge about the experience.
There are many support groups to help with the emotional and physical side effects
of dealing cancer. From online chats to in-person support groups with people that
truly understand your condition, there is something for everyone.
Specific brain tumor support groups have live chats, telephone support, e-mail support
and even in-person support groups.
The National Brain Tumor Foundation offers support to both patients and caregivers.
Join a support group or talk to a brain tumor survivor through the
National Brain Tumor Foundation.
The American Brain Tumor Association provides great tips for living and coping with
brain tumor diagnosis. They even provide a monthly newsletter to keep patients and
caregivers informed on tips for living and coping.
American Brain Tumor Association.
Other sites offer support and education to those looking for general cancer help.
The
National Cancer Institute
allows you to search for support according to cancer type.
MD Anderson Cancer Center Support Programs
offer one-on-one support, online support and group support.
OncoChat
offers emotional support to anyone affected by cancer, it is offered to patients,
caregivers, friends and family of anyone needing emotional support during a difficult
time.
In the next section you’ll find important
questions to ask your doctor
regarding your condition and treatment.
References
Prescribing Information
Important Safety Information
Indications:
GLIADEL® Wafer is indicated in patients with newly diagnosed high-grade
malignant glioma as an adjunct to surgery and radiation. GLIADEL is also indicated
in patients with recurrent glioblastoma multiforme as an adjunct to surgery.
Contraindication:
GLIADEL® Wafer should not be given to patients who have demonstrated
a previous hypersensitivity to carmustine or any of the components of GLIADEL.
Warnings:
Patients undergoing craniotomy for malignant glioma and implantation of GLIADEL
should be monitored closely for known complications of craniotomy, including seizures,
intracranial infections, abnormal wound healing, and brain edema.
Cases of intracerebral mass effect unresponsive to corticosteroids have been described
in patients treated with GLIADEL, including one case leading to brain herniation.
Precautions:
Communication between the surgical resection cavity and the ventricular system should
be avoided to prevent the wafers from migrating into the ventricular system and
causing obstructive hydrocephalus. If a communication larger than the diameter of
a wafer exists, it should be closed prior to wafer implantation.
Computed tomography and magnetic resonance imaging of the head may demonstrate enhancement
in the brain tissue surrounding the resection cavity after implantation of GLIADEL.
This enhancement may represent edema and inflammation caused by GLIADEL or tumor
progression.
The short-term and long-term toxicity profiles of GLIADEL when given in conjunction
with chemotherapy have not been fully explored.
Pregnancy and Nursing:
There are no studies assessing the reproductive toxicity of GLIADEL. Carmustine,
the active component of GLIADEL, can cause fetal harm when administered to a pregnant
woman.
It is recommended that patients receiving GLIADEL discontinue nursing.
Adverse Events:
Seizures:
In the initial surgery trial, the incidence of seizures was 33.3% in patients receiving
GLIADEL and 37.5% in patients receiving placebo. Grand mal seizures occurred in
5% of GLIADEL-treated patients and 4.2% of placebo-treated patients. The incidence
of seizures within the first 5 days after wafer implantation was 2.5% in the GLIADEL
group and 4.2% in the placebo group.
In the surgery for recurrent disease trial, the incidence of post-operative seizures
was 19% in both patients receiving GLIADEL and placebo. In this study, 12/22 (54%)
of patients treated with GLIADEL and 2/22 (9%) of placebo patients experienced the
first new or worsened seizure within the first five post-operative days. The median
time to onset of the first new or worsened post-operative seizure was 3.5 days in
patients treated with GLIADEL and 61 days in placebo patients.
Brain Edema:
In the initial surgery trial, brain edema was noted in 22.5% of patients treated
with GLIADEL and in 19.2% of patients treated with placebo. Development of brain
edema with mass effect (due to tumor recurrences, intracranial infection, or necrosis)
may necessitate re-operation and, in some cases, removal of GLIADEL or its remnants.
Healing Abnormalities:
The following healing abnormalities have been reported in clinical trials of GLIADEL:
wound dehiscence, delayed wound healing, subdural, subgaleal or wound effusions,
and cerebrospinal fluid leak. In the initial surgery trial, healing abnormalities
occurred in 15.8% of GLIADEL-treated patients and in 11.7% of placebo recipients.
Cerebrospinal fluid leaks occurred in 5% of GLIADEL recipients and 0.8% of those
given placebo. During surgery, a water-tight dural closure should be obtained to
minimize the risk of cerebrospinal fluid leak.
In the surgery for recurrent disease trial, the incidence of healing abnormalities
was the 14% of GLIADEL treated patients and 5% in patients receiving placebo wafers.
Intracranial Infection:
In the initial surgery trial, the incidence of brain abscess or meningitis was 5%
in patients treated with GLIADEL and 6% in patients receiving placebo. In the recurrent
setting, the incidence of brain abscess or meningitis was 4% in patients treated
with GLIADEL and 1% in patients receiving placebo.
Please see the Prescribing Information for more information.
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